Mooney K G, Mintun M A, Himmelstein K J, Stella V J
J Pharm Sci. 1981 Jan;70(1):22-32. doi: 10.1002/jps.2600700104.
The dissolution behavior of 2-naphthoic acid from rotating compressed disks into aqueous buffered solutions of constant ionic strength (mu = 0.5 with potassium chloride) at 25 degrees was investigated. A model was developed for the flux of a solid monoprotic carboxylic acid in aqueous buffered solutions as a function of the solution pH and the physicochemical properties of the buffer. The model assumes a diffusion layer-controlled mass transport process and simple, instantaneously established reaction equilibrium between all reactive species (acids and bases) across the diffusion layer. Using intrinsic solubilities, pKa values, and diffusion coefficients, the model accurately predicts the dissolution of 2-naphthoic acid as a function of the bulk solution composition. The concentration profiles of all species across the diffusion layer are generated for each buffer concentration and bulk solution pH, including the pH profile within the microclimate of the diffusion layer and the pH at the solid-solution boundary.
研究了25℃下旋转压缩盘状的2-萘甲酸在离子强度恒定（μ = 0.5，以氯化钾为介质）的水性缓冲溶液中的溶解行为。针对固体一元羧酸在水性缓冲溶液中的通量建立了一个模型，该通量是溶液pH值和缓冲液物理化学性质的函数。该模型假定质量传输过程受扩散层控制，且所有反应物种（酸和碱）在扩散层上能迅速建立简单的反应平衡。利用固有溶解度、pKa值和扩散系数，该模型能准确预测2-萘甲酸的溶解情况与本体溶液组成的函数关系。针对每种缓冲液浓度和本体溶液pH值，生成了扩散层中所有物种的浓度分布，包括扩散层微环境内的pH分布以及固液边界处的pH值。
