Cadwallader D E, Madan D K
J Pharm Sci. 1981 Apr;70(4):442-6. doi: 10.1002/jps.2600700426.
The solubility of cholesterol and some hormone drugs in aqueous macromolecule solutions was investigated. Polyvinylpyrrolidone, dextrans, and heparin increased the solubilities of progesterone, testosterone, and diethylstilbestrol, while acacia, pectin, and carrageenans decreased their solubilities. Dextrans increased the solubilities of cholesterol and the three hormone drugs. Acacia and pectin greatly increased cholesterol solubility; however, these macromolecules significantly decreased progesterone and diethylstilbestrol solubilities and slightly decreased progesterone solubility. Heparin decreased cholesterol solubility and increased progesterone, testosterone, and diethylstilbestrol solubilities. Carrageenans significantly decreased cholesterol, progesterone, and testosterones solubilities and had little effect on diethylstilbestrol solubility. A strong bathochromic shift in the absorption spectra of progesterone and testosterone in polyvinylpyrrolidone solutions indicated an attachment between the polymer and the C=O group of the steroids.
研究了胆固醇和一些激素药物在水性高分子溶液中的溶解度。聚乙烯吡咯烷酮、右旋糖酐和肝素提高了孕酮、睾酮和己烯雌酚的溶解度，而阿拉伯胶、果胶和角叉菜胶则降低了它们的溶解度。右旋糖酐提高了胆固醇和这三种激素药物的溶解度。阿拉伯胶和果胶大大提高了胆固醇的溶解度；然而，这些大分子显著降低了孕酮和己烯雌酚的溶解度，并略微降低了睾酮的溶解度。肝素降低了胆固醇的溶解度，提高了孕酮、睾酮和己烯雌酚的溶解度。角叉菜胶显著降低了胆固醇、孕酮和睾酮的溶解度，对己烯雌酚的溶解度影响不大。孕酮和睾酮在聚乙烯吡咯烷酮溶液中的吸收光谱出现强烈的红移，表明聚合物与甾体的C=O基团之间存在附着作用。
