急性心肌梗死时血清鸟嘌呤酶活性测定的临床与实验研究
Clinical and experimental studies of the determination of serum guanase activity in acute myocardial infarction.
作者信息
Ito S, Takaoka T, Kishi S, Nakaya Y, Hiasa Y, Mori H
出版信息
Jpn Circ J. 1981 May;45(5):525-31. doi: 10.1253/jcj.45.525.
Serum guanase activity was measured by a new method using direct colorimetric determination of ammonia in 25 patients with acute myocardial infarction, 21 dogs with experimental myocardial infarction and 6 CCl4-treated dogs, and compared with serum GOT and GPT activity. We found normal serum guanase activity in patients with acute myocardial infarction and in dogs with experimental myocardial infarction without liver damage, even when the serum GOT and GPT activities increased. On the other hand, serum guanase and transaminase activities were elevated significantly in the patients with acute myocardial infarction who had prominent symptoms of cardiac failure and congestion of the liver and CCl4-treated dogs. These findings suggested that the serum guanase activity was more specific than serum GOT and GPT activity as an indicator of liver damage and determination of serum guanase activity in the patients with acute myocardial infarction might be useful in assessing the presence of liver impairment.
采用一种通过直接比色法测定氨的新方法，对25例急性心肌梗死患者、21只实验性心肌梗死犬和6只四氯化碳处理的犬的血清鸟氨酸酶活性进行了测定，并与血清谷草转氨酶（GOT）和谷丙转氨酶（GPT）活性进行了比较。我们发现，急性心肌梗死患者以及无肝损伤的实验性心肌梗死犬，即使血清GOT和GPT活性升高，其血清鸟氨酸酶活性仍正常。另一方面，有明显心力衰竭和肝充血症状的急性心肌梗死患者以及四氯化碳处理的犬，其血清鸟氨酸酶和转氨酶活性显著升高。这些发现表明，作为肝损伤指标，血清鸟氨酸酶活性比血清GOT和GPT活性更具特异性，测定急性心肌梗死患者的血清鸟氨酸酶活性可能有助于评估肝损伤的存在。
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