Ito S, Tsuji Y
Second Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Gastroenterol Jpn. 1988 Apr;23(2):153-9. doi: 10.1007/BF02799027.
A total of 107 recipients, who did not show any evidence of hepatic disorders in pretransfusional liver function tests and gave a negative reaction for HBsAg, were observed from 3 weeks to 3 months after blood transfusion of 711 units of blood. Of 107 recipients, 18 (17%) developed posttransfusional non-A, non-B hepatitis (PTH). It was detected in 2 of 71 recipients (3%) with blood guanase activities below 3.5 U/L and in 16 of 36 recipients (44%) with blood guanase activities above 3.6 U/L. It is considered that development of PTH could be reduced by avoiding use of donor blood with high guanase activity. We adopted an automated method for measuring guanase in donor blood in the Tokushima Red Cross blood center and examined the incidence of PTH when donor blood with high guanase activity was excluded. Of 112 recipients, 8 (7%) developed PTH. The incidence of PTH was 17% before adoption of the guanase screening test and 7% after its adoption. This work shows that for prevention of PTH it is very important to screen donor blood for guanase activity and discard blood with high guanase activity.
共有107名受血者，他们在输血前肝功能检查中未显示任何肝脏疾病迹象，且乙肝表面抗原（HBsAg）检测呈阴性，在输注711单位血液后的3周内至3个月期间接受了观察。在这107名受血者中，18人（17%）发生了输血后非甲非乙型肝炎（PTH）。在71名血鸟氨酸酶活性低于3.5 U/L的受血者中有2人（3%）检测出该病，而在36名血鸟氨酸酶活性高于3.6 U/L的受血者中有16人（44%）检测出该病。据认为，通过避免使用鸟氨酸酶活性高的供血，可降低PTH的发生率。我们在德岛红十字血液中心采用了一种自动方法来检测供血中的鸟氨酸酶，并在排除鸟氨酸酶活性高的供血后检查了PTH的发生率。在112名受血者中，8人（7%）发生了PTH。在采用鸟氨酸酶筛查试验之前，PTH的发生率为17%，采用之后为7%。这项工作表明，为预防PTH，对供血进行鸟氨酸酶活性筛查并丢弃鸟氨酸酶活性高的血液非常重要。
