Gassmann W, Perenyi L, Schmitz N, Kayser W, Pralle H, Löffler H
Blut. 1982 Jun;44(6):339-48. doi: 10.1007/BF00319917.
In a recently published review of the literature [40] we came to the conclusion that the Ann-Arbor staging classification is of limited prognostic value for chemotherapy of Hodgkin's disease (Table 2). Four risk factors accounted for impaired complete remission rates: stage IVB, lymphocyte depletion or not classifiable histologic type, previous chemotherapy, and older age. Fifty-eight evaluable patients were treated with COPP; 23 reached a complete remission (40%). Disease-free survival was 31%, overall survival 49% after five years [33]. Besides the known risk factors, impaired bone marrow function (leucocyte counts less than 4 X 10(9)/l, platelet counts less than 100 X 10(9)/l) at the start of therapy was associated with poor treatment results: none of six patients achieved a complete remission [41]. Eleven of 16 patients with no and 11 of 23 patients with one risk factor achieved a complete remission, as did only one patient with more than one risk factor. Survival rates after 30 months were: 87% with no, 66% with one, 36% with two, and 13% with more than two risk factors. We can conclude from our results that the prognosis of patients undergoing chemotherapy for Hodgkin's disease depends on the number of risk factors.
在最近发表的一篇文献综述[40]中，我们得出结论：Ann-Arbor分期分类法对霍奇金病化疗的预后价值有限（表2）。四个风险因素导致完全缓解率受损：IVB期、淋巴细胞消减型或无法分类的组织学类型、既往化疗以及高龄。58例可评估患者接受了COPP治疗；23例达到完全缓解（40%）。五年后的无病生存率为31%，总生存率为49%[33]。除了已知的风险因素外，治疗开始时骨髓功能受损（白细胞计数低于4×10⁹/L，血小板计数低于100×10⁹/L）与治疗效果不佳相关：6例患者中无一例达到完全缓解[41]。16例无风险因素的患者中有11例、23例有一个风险因素的患者中有11例达到完全缓解，而有多个风险因素的患者中只有1例达到完全缓解。30个月后的生存率分别为：无风险因素者87%，有一个风险因素者66%，有两个风险因素者36%，有多个风险因素者13%。从我们的结果可以得出结论，接受霍奇金病化疗患者的预后取决于风险因素的数量。
