Romano S, Gizdulich P, Scarpelli P T
Methods Find Exp Clin Pharmacol. 1981 Jan-Feb;3(1):13-5.
Three hypertensive in-patients responsive to a single oral administration of 1 mg prazosin were studied to compare the delays of drug effect on peripheral blood flow (PBF), heart rate (HR) and blood pressure (BP). Arm PBF was measured by venous occlusion strain-gauge plethysmography in a long run session (lasting at least 2 hours) every 5 - 10 minutes. HR and BP were measured accordingly, by conventional methods. The delays of the effect were compared by a cross correlation function of HR, systolic and diastolic BP versus PBF. The results show both advance and delay of HR increase as compared with PBF increase, suggesting some independent mode of action of prazosin at peripheral (vasodilation) and central (HR) level. BP decrease is instead always delayed with respect to PBF increase, by a variable amount (10 - 60 minutes) and with some difference in time response to systolic and diastolic BP, suggesting some independent feed-back loops controlling systolic and diastolic BP adjustment due to primary vasodilation effect.
对三名单次口服1毫克哌唑嗪有反应的高血压住院患者进行了研究，以比较药物对外周血流量（PBF）、心率（HR）和血压（BP）的作用延迟。在一个长时间的实验过程（持续至少2小时）中，每5 - 10分钟通过静脉阻塞应变片体积描记法测量手臂PBF。相应地，通过传统方法测量HR和BP。通过HR、收缩压和舒张压与PBF的互相关函数比较作用延迟。结果显示，与PBF增加相比，HR增加既有提前也有延迟，这表明哌唑嗪在外周（血管舒张）和中枢（HR）水平存在一些独立的作用模式。相反，BP下降相对于PBF增加总是延迟的，延迟时间可变（10 - 60分钟），并且在对收缩压和舒张压的时间反应上存在一些差异，这表明由于主要的血管舒张作用，存在一些独立的反馈回路控制收缩压和舒张压的调节。
