Prazosin-induced vasodilatation of muscle blood vessels in human hypertension. Evidence from strain-gauge plethysmography. Part I.

The fall of blood pressure provoked in hypertensive men by a single oral dose of 1 mg of prazosin is associated with an increase of forearm muscle blood flow. This phenomenon may be demonstrated by a sequence of strain-gauge plethysmographic measurements, taken at regular intervals (5-10 minutes), before and during the action of the drug, lasting more than 2 hours.