Aroney R S, Dalley D N, Chan W K, Bell D R, Levi J A
Med Pediatr Oncol. 1981;9(2):181-6. doi: 10.1002/mpo.2950090212.
Consecutive studies were undertaken in advanced colorectal adenocarcinoma, comparing two different schedules of the combination methyl-CCNU, 6-thioguanine, and 5-fluorouracil in 89 patients. The two schedules exhibited similar efficacies, with a combined complete and partial remission rate of 17%, a median response duration of 36+ weeks, and a median survival of 53+ weeks. Significant symptomatic benefit was seen in 52% of patients. Toxicity was predominantly hemopoietic and gastrointestinal, being acceptable overall, with only minor qualitative differences between the two protocols. These triple-drug regimens exhibit response rates and survival patterns comparable with those reported for other multidrug combinations and some single agents. It would appear that major improvements in the management of advanced-stage disease must await the availability of more efficacious agents used alone or in combination.
对晚期结肠直肠癌患者进行了连续研究，比较了89例患者使用甲基环己亚硝脲、6-硫鸟嘌呤和5-氟尿嘧啶联合化疗的两种不同方案。两种方案疗效相似，完全缓解和部分缓解的联合率为17%，中位缓解持续时间为36 +周，中位生存期为53 +周。52%的患者有显著的症状改善。毒性主要为血液系统和胃肠道毒性，总体上可以接受，两种方案之间只有微小的质量差异。这些三联药物方案的缓解率和生存模式与其他多药联合方案及一些单药报道的情况相当。看来晚期疾病治疗的重大进展必须等待更有效药物单独或联合使用的出现。
