镁对小龙虾神经肌肉接头处易化过程时间进程的影响。
The effect of magnesium on the time course of facilitation at the crayfish neuromuscular junction.
作者信息
Dudel J, Parnas H, Parnas I
出版信息
Neurosci Lett. 1981 Mar 10;22(2):165-8. doi: 10.1016/0304-3940(81)90081-1.
PMID:7231807
Abstract
Synaptic currents (EPSCs) were recorded extracellularly from single junctions. Pairs of EPSCs were elicited at different intervals, the increase of amplitude of the second one facilitation. Elevated Mg concentrations reduced the amplitude of the EPSC and prolonged facilitation. Also, if the amplitude of the EPSCs at high Mg is made the same as in the control, by raising [Ca]0, facilitation is still prolonged. It is concluded that Mg inhibits not only the entry of Ca into the nerve terminal but also its removal.
摘要
突触电流（兴奋性突触后电流，EPSCs）是从单个突触处进行细胞外记录的。以不同的时间间隔诱发成对的EPSCs，第二个EPSC的幅度增加即产生易化作用。升高镁离子浓度会降低EPSC的幅度并延长易化作用。此外，如果通过提高细胞外钙离子浓度（[Ca]0）使高镁离子浓度下的EPSC幅度与对照组相同，易化作用仍然会延长。由此得出结论，镁离子不仅抑制钙离子进入神经末梢，还抑制其移除。
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