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关于抑郁综合征可能的抗胆碱能逆转的临床记录。

Clinical notes on the possible anticholinergic reversal of depressive syndromes.

作者信息

Ungvári G, Karczag I, Gerevich J, Pethö B

出版信息

Pharmacopsychiatria. 1981 Mar;14(2):71-3. doi: 10.1055/s-2007-1019569.

DOI:10.1055/s-2007-1019569
PMID:7232499
Abstract

The authors report on the effects of acute confusional states and deliria (pharmacogenic confusional syndromes - PCS), occurring under the influence of psychotropic drugs on the depressive syndrome of three patients. The favourable influence of PCS on the depressive syndrome is considered to be largely linked to the anticholinergic effect of the drugs. The observations made in these three patients may give support to the hypothesis that cholinergic activity has pathogenic significance in depressive syndromes.

摘要

作者报告了在精神药物影响下出现的急性意识模糊状态和谵妄(药物性意识模糊综合征-PCS)对三名患者抑郁综合征的影响。PCS对抑郁综合征的有利影响在很大程度上被认为与药物的抗胆碱能作用有关。对这三名患者的观察结果可能支持胆碱能活性在抑郁综合征中具有致病意义这一假说。

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