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降钙素和促胰液素可抑制蛙皮素刺激的人血清胃泌素及胃酸分泌。

Calcitonin and secretin inhibit bombesin-stimulated serum gastrin and gastric acid secretion in man.

作者信息

Jansen J B, Lamers C B

出版信息

Regul Pept. 1981 Mar;1(6):415-21. doi: 10.1016/0167-0115(81)90044-6.

DOI:10.1016/0167-0115(81)90044-6
PMID:7232773
Abstract

The effect of intravenously administered calcitonin and secretin on bombesin-stimulated serum gastrin and gastric acid secretion was studied on 7 volunteers. Secretin G.I.H. (1 C.U./kg per h) and calcitonin (0.5 I.U./kg per h) significantly (P less than 0.05) inhibited the serum gastrin and gastric acid responses to bombesin-14 (90 pmol/kg per h). Inhibition of gastrin release could not fully account for the inhibition of gastric acid secretion.

摘要

对7名志愿者研究了静脉注射降钙素和促胰液素对蛙皮素刺激的血清胃泌素及胃酸分泌的影响。促胰液素(胃肠激素)(每小时1单位/千克)和降钙素(每小时0.5国际单位/千克)显著(P<0.05)抑制了对蛙皮素-14(每小时90皮摩尔/千克)的血清胃泌素及胃酸反应。胃泌素释放的抑制不能完全解释胃酸分泌的抑制。

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Regul Pept. 1981 Mar;1(6):415-21. doi: 10.1016/0167-0115(81)90044-6.
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引用本文的文献

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Changes of Gastric Secretion after Bolus and Slow Intravenous Administration of Bombesin and Neurotensin.静脉推注和缓慢静脉注射蛙皮素与神经降压素后胃分泌的变化
Maedica (Bucur). 2021 Dec;16(4):642-655. doi: 10.26574/maedica.2021.16.4.642.
2
Role of endogenous secretin in acid-induced inhibition of human gastric function.内源性促胰液素在酸诱导的人胃功能抑制中的作用。
J Clin Invest. 1984 Feb;73(2):526-32. doi: 10.1172/JCI111239.
3
Secretin provocation in normal and duodenal ulcer subjects. Is the gastrin rise in Zollinger-Ellison syndrome paradoxic or exaggeration?
正常人和十二指肠溃疡患者的促胰液素激发试验。卓-艾综合征中胃泌素升高是反常现象还是过度反应?
Dig Dis Sci. 1987 Mar;32(3):232-8. doi: 10.1007/BF01297046.