可溶性和颗粒性葡聚糖的肿瘤抑制及抗菌活性的比较评估

Comparative evaluation of the tumor inhibitory and antibacterial activity of solubilized and particulate glucan.

作者信息

di Luzio N R, Williams D L, McNamee R B, Malshet V G

出版信息

Recent Results Cancer Res. 1980;75:165-72. doi: 10.1007/978-3-642-81491-4_26.

Abstract

A soluble derivative of particulate glucan was prepared and evaluated for its antitumor and antibacterial activity. Intravenous administration of soluble or particulate glucan resulted in significant reduction in the growth of a syngeneic anaplastic mammary carcinoma and melanoma B16 and enhanced survival. Soluble and particulate glucan also significantly enhanced survival of mice infected with Staphylococcus aureus. Hepatosplenomegaly and granuloma formation observed in particulate glucan-treated mice were not observed in the soluble glucan group. It is evident that the soluble glucan initiates significant antitumor and antistaphylococcal activity. The active soluble fraction of particulate glucan may be preferable to particulate glucan in view of inherent facility of parenteral administration.

摘要

制备了一种颗粒状葡聚糖的可溶性衍生物，并对其抗肿瘤和抗菌活性进行了评估。静脉注射可溶性或颗粒状葡聚糖可显著降低同基因间变性乳腺癌和黑色素瘤B16的生长，并提高生存率。可溶性和颗粒状葡聚糖还显著提高了感染金黄色葡萄球菌的小鼠的生存率。在可溶性葡聚糖组中未观察到颗粒状葡聚糖处理的小鼠中出现的肝脾肿大和肉芽肿形成。显然，可溶性葡聚糖具有显著的抗肿瘤和抗葡萄球菌活性。鉴于肠胃外给药的固有便利性，颗粒状葡聚糖的活性可溶性部分可能比颗粒状葡聚糖更可取。