Patchen M L, MacVittie T J
J Immunopharmacol. 1986;8(3):407-25.
A soluble form of the reticuloendothelial- and immune modulating agent glucan (glucan-F) has been evaluated for its effects on hemopoiesis. A single 5.0 mg intravenous injection of glucan-F into C3H/HeN mice increased peripheral white blood cellularity, bone marrow and splenic cellularity, bone marrow and splenic granulocyte-macrophage progenitor cell numbers (GM-CFC), and splenic pluripotent stem cell (CFU-s) and erythroid progenitor cell (CFU-e) numbers. Serum levels of granulocyte-macrophage colony stimulating activity (CSA) were also elevated following glucan-F administration. These hemopoietic responses correlate well with those previously shown to be induced by intravenous administration of particulate glucan (glucan-P). In contrast to glucan-P, however, intravenous glucan-F administration has been shown not to induce granuloma formation and severe hepatosplenomegaly, thus the potential clinical use of glucan-F as a hemopoietic stimulant is more likely than that of glucan-P.
已对一种可溶性网状内皮细胞和免疫调节剂葡聚糖（葡聚糖 - F）对造血作用的影响进行了评估。向C3H/HeN小鼠静脉内单次注射5.0毫克葡聚糖 - F，可增加外周白细胞数量、骨髓和脾脏细胞数量、骨髓和脾脏粒细胞 - 巨噬细胞祖细胞数量（GM - CFC），以及脾脏多能干细胞（CFU - s）和红系祖细胞（CFU - e）数量。给予葡聚糖 - F后，血清粒细胞 - 巨噬细胞集落刺激活性（CSA）水平也升高。这些造血反应与先前静脉注射颗粒状葡聚糖（葡聚糖 - P）所诱导的反应密切相关。然而，与葡聚糖 - P不同，静脉注射葡聚糖 - F未显示会诱导肉芽肿形成和严重肝脾肿大，因此葡聚糖 - F作为造血刺激剂的潜在临床应用比葡聚糖 - P更具可能性。
