Riley V
Science. 1981 Jun 5;212(4499):1100-9. doi: 10.1126/science.7233204.
Emotional, psychosocial, or anxiety-stimulated stress produces increased plasma concentrations of adrenal corticoids and other hormones though well-known neuroendocrine pathways. A direct consequence of these increased corticoid concentrations is injury to elements of the immunological apparatus, which may leve the subject vulnerable to the action of latent oncogenic viruses, newly transformed cancer cells, or other incipient pathological processes that are normally held in check by an intact immunological apparatus. This article describes studies that examine the adverse effects of increased plasma concentrations of adrenal corticoids on the thymus and thymus-dependent T cells, inasmuch as these elements constitute a major defense system against various neoplastic processes and other pathologies. The studies demonstrate that anxiety-stress can be quantitatively induced and the consequences measured through specific biochemical and cellular parameters, providing that authentic quiescent baselines of these conditions are obtained in the experimental animals by the use of low-stress protective housing and handling techniques.
情绪、心理社会或焦虑引发的应激通过众所周知的神经内分泌途径导致血浆中肾上腺皮质激素和其他激素浓度升高。这些皮质激素浓度升高的直接后果是免疫器官的组成部分受到损伤，这可能使个体易受潜伏致癌病毒、新转化的癌细胞或其他初始病理过程的影响，而这些过程通常会被完整的免疫器官所抑制。本文描述了一些研究，这些研究探讨了血浆中肾上腺皮质激素浓度升高对胸腺和胸腺依赖性T细胞的不利影响，因为这些成分构成了抵御各种肿瘤过程和其他病理状况的主要防御系统。研究表明，只要通过使用低应激的保护性饲养和处理技术在实验动物中获得这些条件的真实静止基线，焦虑应激就可以被定量诱导，其后果也可以通过特定的生化和细胞参数来测量。
