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丙吡胺及其他类似抗心律失常药物诱发的室性快速性心律失常。

Ventricular tachyarrhythmias induced by disopyramide and other similar anti-arrhythmic drugs.

作者信息

Croft C H, Kennelly B M

出版信息

S Afr Med J. 1981 Jun 6;59(24):871-3.

PMID:7233313
Abstract

Two patients with atrial arrhythmias are described who developed ventricular tachyarrhythmias shortly after starting disopyramide therapy. One patient had manifested ventricular tachycardia while on quinidine therapy earlier and the other patient, who died, had survived ventricular tachycardia and fibrillation complicating both quinidine and lidoflazine therapy 5 years earlier. We advise against the use of lidoflazine in patients with previously documented 'quinidine syncope' and caution that ventricular tachyarrhythmias appearing for the first time with the administration of disopyramide should be considered to be drug-induced until proved otherwise.

摘要

本文描述了两名心房心律失常患者,他们在开始丙吡胺治疗后不久出现了室性快速心律失常。一名患者在早期使用奎尼丁治疗时曾出现室性心动过速,另一名患者死亡,该患者曾在5年前因奎尼丁和利多氟嗪治疗并发室性心动过速和颤动而存活下来。我们建议,对于既往有“奎尼丁晕厥”记录的患者,应避免使用利多氟嗪,并提醒在使用丙吡胺首次出现室性快速心律失常时,在未得到其他证实之前应考虑为药物所致。

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