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神经修复的重新评估

Reappraisal of nerve repair.

作者信息

Millesi H

出版信息

Surg Clin North Am. 1981 Apr;61(2):321-40. doi: 10.1016/s0039-6109(16)42384-4.

Abstract

In every case of acute injury involving the nerve, the surgeon must decide whether a primary repair of an elective early secondary repair is the treatment of choice. In a clean-cut nerve without defect, immediate primary repair, using trunk-to-trunk coaptation with epineurial sutures, offers an optimal solution. In the periphery of the median and the ulnar nerves, in which motor and sensory fascicles are already separated, fascicular dissection is performed, and coaptation of fascicle groups should be done. In medical centers with excellent facilities, such nerve repair will give good results even in very severe lesions. This repair can be performed also as a delayed primary procedure. If there is a nerve defect, a primary grafting procedure must be considered. We do not recommend this as a routine procedure because the nerve grafts might be lost if a complication occurs. The decision to perform a planned early secondary repair is an equally good alternative, especially in cases of a nerve defect, severe concomitant injuries, or both. In case of a combined nerve and tendon lesion in the carpal tunnel, the nerve repair can be performed at a later procedure without exposing the repaired flexor tendons, thus avoiding adhesion between tendons and nerves. If a decision is made in favor of an early secondary repair, the two stumps can be approximated by stitches to prevent retraction, if this can be achieved without tension. Approximation under tension in case of a larger defect would damage the two stumps and create an even larger defect. Marking the nerve ends by sutures is not necessary because exploration with always start in normal tissue, exposing the nerves from the proximal or the distal segments. Early secondary repair is performed during the third week, or later if this is demanded by local conditions. When indicated, plastic surgical procedures can eliminate constricting scars and provide an optimal soft tissue environment. After exploration and preparation of the two stumps, the surgeon must decide whether direct suturing or a nerve graft is indicated. If after very limited mobilization and slight flexion the nerve stumps cannot be coapted easily, a nerve graft should be used. The quality of motor recovery decreases steadily after a 6 month delay of repair. Late secondary repairs or reoperation of failure of primary repair should be performed within this time limit, although this does not mean that motor recovery cannot occur after a longer time interval. Useful motor recovery was achieved in certain cases after 18 months or more. Obviously the results might have been better if the time interval had been shorter. If a patient is seen with a nerve lesion after a long time interval, nerve repair is still indicated if sensibility is the main functional objective. In other long-standing cases, the nerve repair is combined with tendon transfer or capsulorrhaphy. After a particularly long time interval or in old patients, only palliative surgery is indicated.

摘要

在每例涉及神经的急性损伤中,外科医生必须决定是进行一期修复还是选择性早期二期修复作为首选治疗方法。对于无缺损的锐器切割伤神经,采用神经干对神经干外膜缝合的即时一期修复是最佳解决方案。在正中神经和尺神经的外周区域,运动和感觉束已经分开,应进行束间解剖,并对束组进行对接。在设施完善的医疗中心,即使是非常严重的损伤,这种神经修复也能取得良好效果。这种修复也可作为延迟一期手术进行。如果存在神经缺损,则必须考虑一期移植手术。我们不建议将其作为常规手术,因为如果发生并发症,神经移植物可能会丢失。决定进行计划性早期二期修复同样是一个不错的选择,尤其是在存在神经缺损、严重合并伤或两者皆有的情况下。在腕管内神经和肌腱合并损伤的情况下,神经修复可在后期进行,而无需暴露已修复的屈肌腱,从而避免肌腱与神经之间的粘连。如果决定进行早期二期修复,若能在无张力的情况下实现,可用缝线使两断端靠近以防止回缩。在缺损较大的情况下进行有张力的靠近会损伤两断端并造成更大的缺损。无需用缝线标记神经断端,因为探查总是从正常组织开始,从近端或远端暴露神经。早期二期修复在第三周进行,或根据局部情况在更晚的时候进行。如有需要,整形手术可消除狭窄瘢痕并提供最佳的软组织环境。在探查并准备好两断端后,外科医生必须决定是进行直接缝合还是使用神经移植物。如果在非常有限的游离和轻微屈曲后神经断端仍难以对接,则应使用神经移植物。修复延迟6个月后运动恢复质量会持续下降。晚期二期修复或一期修复失败后的再次手术应在这个时间限制内进行,尽管这并不意味着更长时间间隔后就不会有运动恢复。在某些情况下,18个月或更长时间后仍实现了有用的运动恢复。显然,如果时间间隔更短,结果可能会更好。如果在很长时间间隔后发现患者有神经损伤,若感觉是主要功能目标,仍应进行神经修复。在其他长期病例中,神经修复与肌腱转移或关节囊缝合相结合。在间隔时间特别长或老年患者中,仅需进行姑息性手术。

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