Marion A, Lesko L J, Oliver C
Ther Drug Monit. 1981;3(1):107-8.
We described potential interference of procainamide with our high pressure liquid chromatography procedure for assaying theophylline (similar to that given by Orcutt et al.). In participating in the AACC-TDM quality-control program, we discovered procainamide interference on a column dedicated to theophylline and acetaminophen serum analyses. Following attempts at rejuvenation, this 7-month-old column was replaced with a new one, which gave base-line separation of theophylline and procainamide with no difficulty. We recommend close attention to the aging characteristics of columns and participation in a quality-control program.
我们描述了普鲁卡因胺对我们用于测定茶碱的高压液相色谱法可能产生的干扰（类似于奥克特等人所给出的干扰情况）。在参与美国临床化学协会（AACC）的治疗药物监测（TDM）质量控制项目时，我们发现在一根专门用于茶碱和对乙酰氨基酚血清分析的色谱柱上存在普鲁卡因胺干扰。在尝试对这根使用了7个月的色谱柱进行修复后，我们更换了一根新柱，它能轻松实现茶碱和普鲁卡因胺的基线分离。我们建议密切关注色谱柱的老化特性并参与质量控制项目。
