奥芬达唑对猪的驱虫活性。

Anthelmintic activity of oxfendazole in pigs.

作者信息

Kingsbury P A, Rowlands D T, Reid J F

出版信息

Vet Rec. 1981 Jan 3;108(1):10-1. doi: 10.1136/vr.108.1.10.

DOI:10.1136/vr.108.1.10

Abstract

Eighty-five pigs were artificially infected with Hyostrongylus rubidus, Oesophagostomum species and Ascaris suum. On days 2, 10, 20 or 51 after infection groups of six were treated with oxfendazole premix in food at various dose rates. Subsequently the pigs were slaughtered for comparative worm counts to be made in treated and control animals. The efficacy of treatment against hyostrongylus worms of increasing age was 68, 57, 99.8 and 100 per cent after a 3 mg per kg dose, 75, 75, 99.8 and 100 per cent after a 4.5 mg per kg dose and 81, 83, 99.8 and 100 per cent after a 6 mg per kg dose. In the case of Oesophagostomum species the corresponding figures were 78, 100, 100 and 100 per cent efficacy after a 3 mg dose, 93, 100, 100 and 100 per cent after a 4.5 mg per kg dose and 91, 99, 100 and 100 per cent after a 6 mg per kg dose. Ascaris infestation established too poorly for significant results to be obtained. It is concluded that a dose rate of 4.5 mg oxfendazole per kg body-weight should give practical control of Hyostrongylus and Oesophagostomum species in pigs.

摘要

85头猪被人工感染了红色猪圆线虫、结节虫属和猪蛔虫。在感染后的第2天、第10天、第20天或第51天，每组6头猪分别以不同剂量率在饲料中添加奥芬达唑预混剂进行治疗。随后将猪宰杀，对治疗组和对照组动物进行比较性的蠕虫计数。对于不同日龄的猪，每千克体重3毫克剂量的奥芬达唑对红色猪圆线虫的驱虫效果分别为68%、57%、99.8%和100%；每千克体重4.5毫克剂量的驱虫效果分别为75%、75%、99.8%和100%；每千克体重6毫克剂量的驱虫效果分别为81%、83%、99.8%和100%。对于结节虫属，每千克体重3毫克剂量的驱虫效果分别为78%、100%、100%和100%；每千克体重4.5毫克剂量的驱虫效果分别为93%、100%、100%和100%；每千克体重6毫克剂量的驱虫效果分别为91%、99%、100%和100%。猪蛔虫感染情况不佳，未能获得显著结果。结论是每千克体重4.5毫克的奥芬达唑剂量可有效控制猪体内的红色猪圆线虫和结节虫属。