Corwin R M
Am J Vet Res. 1977 Apr;38(4):465-7.
Sixty feeder pigs with mixed naturally acquired nematode infections were medicated with oxfendazole, a new benzimidazolecarbamate compound, at dose levels of 0, 3, 9, and 18 mg/kg of body weight. The dosage of 3.0 mg/kg administered once in the feed proved as efficacious as larger dosages and the same dosage administered 2 or 3 times in the removal of adult Ascaris suum, Oesophagostomum dentatum, and Metastrongylus pudendotectus. Trichuris suis adults were less susceptible. Anthelmintic efficacy was based upon comparative nematode egg counts, appearance of eggs, and recovered nematode burdens at necropsy. Signs of toxicosis were not seen in pigs given any one of the medicated feed schedules.
六十头自然感染多种线虫的育肥猪，分别按0、3、9和18毫克/千克体重的剂量水平，用一种新型苯并咪唑氨基甲酸酯化合物奥芬达唑进行给药。在饲料中一次性投喂3.0毫克/千克的剂量，在清除猪蛔虫、有齿食道口线虫和猪后圆线虫成虫方面，证明与较大剂量以及同样剂量分2次或3次投喂的效果相同。猪鞭虫成虫对此药较不敏感。驱虫效果是根据剖检时线虫卵计数的比较、虫卵外观以及回收的线虫数量来判定的。在采用任何一种给药饲料方案的猪中，均未观察到中毒迹象。
