Habibi B, Cartron J P, Bretagne M, Rouger P, Salmon C
Vox Sang. 1981 Feb;40(2):79-84. doi: 10.1111/j.1423-0410.1981.tb00673.x.
An anti-Nomifensine antibody was identified in a patient with immune hemolysis and renal failure who was under Nomifensine therapy. The anti-drug specificity of the antibody was confirmed by inhibition assays using Sepharose gel-Nomifensine conjugates. Preliminary screening tests for anti-Nomifensine antibody in a population of 104 patients treated by the drug showed no further example of such immunization.
在接受诺米芬辛治疗的一名免疫性溶血和肾衰竭患者体内发现了一种抗诺米芬辛抗体。使用琼脂糖凝胶 - 诺米芬辛结合物进行的抑制试验证实了该抗体的抗药物特异性。对104名接受该药物治疗的患者群体进行的抗诺米芬辛抗体初步筛查试验未发现此类免疫反应的其他病例。
