Martlew V J
J Clin Pathol. 1986 Oct;39(10):1147-50. doi: 10.1136/jcp.39.10.1147.
Nomifensine, an antidepressant used for eight years in Britain, was particularly popular in the north west of England. Haemolytic anaemia was recognised as a rare side effect, but in 1984 a cluster of six cases was referred to the North West Regional Transfusion Centre, reflecting an incidence of 0.006%. These were collected within 18 months and showed variable serological features, indicating that antibodies associated with nomifensine treatment are neither rare nor of one particular type. The accumulation of this and similar data contributed to its withdrawal from the British market in January, 1986.
诺米芬辛是一种在英国使用了八年的抗抑郁药，在英格兰西北部尤其受欢迎。溶血性贫血被认为是一种罕见的副作用，但在1984年，有六例该病例被转诊至西北区域输血中心，发病率为0.006%。这些病例在18个月内收集，呈现出不同的血清学特征，表明与诺米芬辛治疗相关的抗体既不罕见也不是某一种特定类型。这些以及类似数据的积累促使其于1986年1月从英国市场撤出。
