Boggan J E, Hoff J T, Wara W M, Boldrey E B
West J Med. 1980 Aug;133(2):108-14.
Thirty cases of intraspinal neoplasms occurring during the first two decades of life are reviewed. Histologic examination showed 13 of these to be astrocytomas, 6 neuroblastomas, 5 sarcomas, 3 ependymomas, 2 neurofibromas and 1 a schwannoma. Orthopedic deformities developed or worsened in 60 percent of patients surviving longer than a year after diagnosis. In five patients some form of endocrine deficiency developed after irradiation. For treatment of radiosensitive extradural malignant lesions, biopsy followed by irradiation is advocated.
回顾了20岁前发生的30例脊髓内肿瘤。组织学检查显示,其中13例为星形细胞瘤,6例为神经母细胞瘤,5例为肉瘤,3例为室管膜瘤,2例为神经纤维瘤,1例为施万细胞瘤。诊断后存活超过1年的患者中,60%出现或加重了骨科畸形。5例患者在放疗后出现了某种形式的内分泌缺乏。对于放射敏感的硬膜外恶性病变,主张先活检再放疗。