Von Kleist D, Staud R, Stopik D, Hampel K E
Z Gastroenterol. 1981 Mar;19(3):135-9.
The effect of calcitonin (salmon-calcitonin) on PD taken from the gastric juice was measured in 19 volunteers and compared with controls given saline solution (n = 14). The PD measurements in the gastric juice were done under fluoroscopic or under endoscopic control. After bolus injection of calcitonin (100 MRCU) a rapid and significant (p less than 0.05) increase in PD taken from the gastric juice was observed within 15 min. This increase remained almost unchanged for 2 hours. With the endoscopically directed electrode increases in PD could be also detected in the fundus, in the body of the stomach and in the antrum but not in the duodenum mucosa. In contrast to the increase in the antrum mucosa there was a more significant increase in PD in the fundus and in the body of the stomach. This difference could be discussed as a specific effect of calcitonin on the parietal cells.
在19名志愿者中测量了降钙素（鲑鱼降钙素）对取自胃液的电位差（PD）的影响，并与给予生理盐水的对照组（n = 14）进行比较。胃液中PD的测量在荧光镜或内镜控制下进行。静脉注射降钙素（100 MRCU）后，在15分钟内观察到取自胃液的PD迅速且显著（p < 0.05）增加。这种增加在2小时内几乎保持不变。使用内镜导向电极，在胃底、胃体和胃窦中也可检测到PD增加，但十二指肠黏膜中未检测到。与胃窦黏膜的增加相比，胃底和胃体中的PD增加更为显著。这种差异可被视为降钙素对壁细胞的特异性作用。
