Doepfner W, Buiner U, Ohnhaus E
Z Gastroenterol Verh. 1976(10):60-70.
In conscious and unrestrained cats the gastric secretion and ulcer formation induced by i.v. infusion of pentagastrin can be inhibited by synthetic salmon calcitonin given simultaneously. The volume and various constituents of gastric juice are proportionally diminished. Pepsin alone is definitely more inhibited, which may be of significance in respect to the mode of action of calcitonin. These effects are dose dependent in the range of 0.01 mug - 1.0 mug/kg/h salmon calcitonin, corresponding to 0.05 - 5.0 MRC units. Based on the finding that such minute doses have effects, it may be speculated that calcitonin has a regulatory function in gastric secretion of cats. In Shay-rats a dose dependent inhibitory effect of salmon calcitonin on ulcer formation and gastric secretion is demonstrated. Besides the volume, the acid concentration of gastric juice is reduced, which may explain the high efficacy of salmon calcitonin to prevent ulcer formation in this species. Ulcerations induced by pylorus ligation, stress and phenylbutazone can be inhibited to a similar degree by calcitonin, suggesting interference with a basal mechanism common to all three types of ulcerogenesis.
在清醒且未受约束的猫中，静脉输注五肽胃泌素所诱导的胃液分泌和溃疡形成可被同时给予的合成鲑鱼降钙素抑制。胃液的体积和各种成分成比例减少。单独的胃蛋白酶受到的抑制更明显，这可能与降钙素的作用方式有关。在0.01微克 - 1.0微克/千克/小时的鲑鱼降钙素范围内，这些作用呈剂量依赖性，相当于0.05 - 5.0 MRC单位。基于如此小剂量就有作用这一发现，可以推测降钙素在猫的胃液分泌中具有调节功能。在沙伊大鼠中，证明了鲑鱼降钙素对溃疡形成和胃液分泌有剂量依赖性抑制作用。除了体积外，胃液的酸浓度也降低，这可能解释了鲑鱼降钙素在该物种中预防溃疡形成的高效性。幽门结扎、应激和保泰松诱导的溃疡可被降钙素以相似程度抑制，提示其干扰了所有三种溃疡形成类型共有的基础机制。
