Komuro N, Ohishi M, Kurashima T, Yokoyama S, Ohsuka H, Ito H
Acta Obstet Gynaecol Jpn. 1981 Feb;33(2):169-77.
From 89 cases of invasive mole, collected by our department since 1948, 12 (13.5%) cases without preceding hydatidiform mole (group A) were taken out, and their clinical data and histological observations were studied in comparison with those preceded by hydatidiform mole (group B) in the remaining 77 (86.5%), with the following results: 1. Invasive mole in group A was preceded by artificial or spontaneous abortion, but not by premature or normal delivery. 2. All of the 12 cases developed the invasive mole within 6 months. 3. Relation between the size of the focus and the latency period was not observed in either of the two groups. 4. The incidence of preoperative metastasis was somewhat lower in group A, but no difference was visible between the two groups in prognostic result. 5. As for histological findings, edematization and vesiculation of stroma of villi were observed in all the cases of group A, though with difference in grade from case to case. These findings as well as proliferation and intervascular penetration of villous cells were similar to those of group B.
自1948年以来，我科收集了89例侵袭性葡萄胎病例，从中选出12例（13.5%）无前驱葡萄胎的病例（A组），并将其临床资料和组织学观察结果与其余77例（86.5%）有前驱葡萄胎的病例（B组）进行比较，结果如下：1. A组侵袭性葡萄胎之前有人工流产或自然流产史，但无早产或正常分娩史。2. 12例均在6个月内发生侵袭性葡萄胎。3. 两组均未观察到病灶大小与潜伏期之间的关系。4. A组术前转移发生率略低，但两组预后结果无差异。5. 组织学检查发现，A组所有病例均见绒毛间质水肿和水泡样变，虽程度各异。这些表现以及绒毛细胞的增殖和血管间浸润与B组相似。
