Jeffers M D, O'Dwyer P, Curran B, Leader M, Gillan J E
Department of Pathology, Rotunda Hospital, Dublin, Ireland.
Int J Gynecol Pathol. 1993 Oct;12(4):315-23.
This retrospective study reports the incidence of hydatidiform mole in a population of 19,457 pregnancies over a 3-year period. During the study period all "products of conception" from first and second trimester abortions were referred for pathological examination. Coded histologic sections were reviewed using the published histologic criteria for hydatidiform mole. Ploidy was estimated by DNA flow cytometry. Clinical data were retrieved from maternal case notes. Thirty-eight cases were confirmed as hydatidiform mole, 10 (26%) as complete mole, and 28 (74%) as partial mole. Twenty-three cases of partial mole (88%) were triploid, and nine of 10 complete moles were diploid. The incidence of hydatidiform mole was 1:512 pregnancies, (complete mole, 1:1,945; partial mole, 1:695). Only one case (3.5%) of partial mole was suspected clinically. One case of persistent gestational trophoblastic disease occurred following a complete mole. No sequelae were encountered following partial mole. We conclude that hydatidiform mole is a common condition and the majority of cases are partial moles. Quantitatively imprecise morphologic criteria contribute to the inaccuracy in reporting of partial mole; analysis of ploidy is useful in the evaluation of problem cases. Follow-up of partial mole is warranted because its true biological potential is as yet unclear.
这项回顾性研究报告了在3年期间19457例妊娠人群中葡萄胎的发病率。在研究期间，所有孕早期和孕中期流产的“妊娠产物”均被送去做病理检查。根据已发表的葡萄胎组织学标准对编码的组织学切片进行复查。通过DNA流式细胞术估计倍性。临床数据从产妇病历中获取。38例被确诊为葡萄胎，其中10例（26%）为完全性葡萄胎，28例（74%）为部分性葡萄胎。23例部分性葡萄胎（88%）为三倍体，10例完全性葡萄胎中有9例为二倍体。葡萄胎的发病率为1:512次妊娠（完全性葡萄胎为1:1945；部分性葡萄胎为1:695）。临床上仅怀疑1例（3.5%）部分性葡萄胎。1例完全性葡萄胎后发生持续性滋养细胞疾病。部分性葡萄胎后未出现后遗症。我们得出结论，葡萄胎是一种常见疾病，大多数病例为部分性葡萄胎。形态学标准在数量上不精确导致了部分性葡萄胎报告的不准确；倍性分析有助于评估疑难病例。部分性葡萄胎需要进行随访，因为其真正的生物学潜能尚不清楚。
