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肠病性肢端皮炎 锌治疗后脑萎缩的可逆性

Acrodermatitis enteropathica Reversibility of cerebral atrophy with zinc therapy.

作者信息

Ohlsson A

出版信息

Acta Paediatr Scand. 1981 Mar;70(2):269-73. doi: 10.1111/j.1651-2227.1981.tb05556.x.

DOI:10.1111/j.1651-2227.1981.tb05556.x
PMID:7234413
Abstract

A six-month-old Saudi boy with acrodermatitis enteropathica confirmed by low serum zinc and alkaline phosphatase levels is described. Both the patient and a sibling developed acrodermatitis enteropathica while entirely breastfed. The mother had low serum zinc levels. Cranial computed tomography initially showed marked central and cortical "atrophy" that improved on treatment with zinc sulphate. The importance of zinc for normal brain growth and function is well known and the improvement on cranial computed tomography could be explained by improved myelination.

摘要

描述了一名6个月大的沙特男孩,其血清锌和碱性磷酸酶水平低,确诊为肠病性肢端皮炎。该患者及其一名兄弟姐妹在完全母乳喂养期间均患上了肠病性肢端皮炎。母亲的血清锌水平较低。头颅计算机断层扫描最初显示明显的中央和皮质“萎缩”,经硫酸锌治疗后有所改善。锌对正常脑生长和功能的重要性是众所周知的,头颅计算机断层扫描的改善可以用髓鞘形成改善来解释。

相似文献

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Acrodermatitis enteropathica Reversibility of cerebral atrophy with zinc therapy.肠病性肢端皮炎 锌治疗后脑萎缩的可逆性
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[Zinc in the therapy of acrodermatitis enteropathica].
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Lancet. 1974 Aug 17;2(7877):399-400. doi: 10.1016/s0140-6736(74)91772-3.

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Mol Cell Biol. 2005 Jul;25(13):5607-15. doi: 10.1128/MCB.25.13.5607-5615.2005.
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Acrodermatitis enteropathica.肠病性肢端皮炎
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