Hardebo J E, Edvinsson L, Johansson B B
Acta Physiol Scand. 1980 Dec;110(4):375-9. doi: 10.1111/j.1748-1716.1980.tb06683.x.
Electrical stimulation of the sympathetic nerves to the cerebrovascular bed enables the resistance vessels to better withstand a high blood pressure in terms of blood-brain barrier integrity. Sympathetic denervation could hence be expected to lead to a decrease in cerebrovascular tone and increased vulnerability of the blood-brain barrier. In the present study acute hypertension was induced in conscious unrestrained rats by administration of angiotensin or bicuculline. The albumin leakage into the brain, as studied by Evans blue-albumin and 125I labelled human serum albumin, was not enhanced in acutely or chronically sympathectomized rats compared to controls.
对脑血管床的交感神经进行电刺激，就血脑屏障完整性而言，可使阻力血管更好地耐受高血压。因此，可以预期交感神经去支配会导致脑血管张力降低以及血脑屏障的脆弱性增加。在本研究中，通过给予血管紧张素或荷包牡丹碱在清醒不受束缚的大鼠中诱发急性高血压。与对照组相比，通过伊文思蓝 - 白蛋白和125I标记的人血清白蛋白研究发现，急性或慢性交感神经切除的大鼠脑内白蛋白渗漏并未增加。
