Yunus M, Calabro J J, Miller K A, Masi A T
Am J Med. 1981 Jun;70(6):1210-4. doi: 10.1016/0002-9343(81)90829-9.
Twelve consecutive patients with Reiter's syndrome, nine with the B27 antigen (B27 positive) and three without (B27 negative), and their 45 first degree relatives were studied clinically and with HLA typing. Two of the four adult male first degree relatives with the B27 antigen had classic Reiter's syndrome. In addition, one of two B27 positive adult male second degree relatives studied in one family had classic Reiter's syndrome. The data, although limited, suggest that the familial occurrence of Reiter's syndrome is higher than previously recognized, especially in adult male first degree relatives with the B27 antigen, and is similar to the degree of familial aggregation reported in ankylosing spondylitis.
对12例连续性赖特综合征患者、9例携带B27抗原者（B27阳性）和3例未携带B27抗原者（B27阴性）及其45名一级亲属进行了临床研究和HLA分型。4名携带B27抗原的成年男性一级亲属中有2人患有典型的赖特综合征。此外，在一个家族中研究的2名B27阳性成年男性二级亲属中有1人患有典型的赖特综合征。这些数据虽然有限，但表明赖特综合征的家族发病率高于先前的认识，尤其是在携带B27抗原的成年男性一级亲属中，并且与强直性脊柱炎报道的家族聚集程度相似。
