LeClercq S A, Chaput L, Russell A S
J Rheumatol. 1983 Aug;10(4):629-32.
Of the first degree relatives of B27 positive spondylitis probands, 10.2% demonstrated an associated disease, i.e., ankylosing spondylitis, Reiter's syndrome, peripheral arthritis, or acute anterior uveitis; all were B27 positive. Eighteen, i.e., only 13.7% of the B27 positive subjects had sacroiliitis; 4 were asymptomatic. We would therefore caution against the previous over-estimation of disease prevalence in "randomly selected" HLA-B27 positive individuals. None of the B27 negative relatives had any uveitis or spondyloarthropathy.
在B27阳性的脊柱关节炎先证者的一级亲属中，10.2%患有相关疾病，即强直性脊柱炎、赖特综合征、外周关节炎或急性前葡萄膜炎；所有患者B27均为阳性。18名B27阳性受试者（即仅占13.7%）患有骶髂关节炎；其中4人无症状。因此，我们要提醒注意，以往对“随机选择”的HLA - B27阳性个体的疾病患病率估计过高。B27阴性的亲属均未患葡萄膜炎或脊柱关节病。
