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中央桥脑髓鞘溶解症中外侧膝状体核的脱髓鞘改变

Demyelination of the lateral geniculate nucleus in central pontine myelinolysis.

作者信息

Goldman J E, Horoupian D S

出版信息

Ann Neurol. 1981 Feb;9(2):185-9. doi: 10.1002/ana.410090213.

DOI:10.1002/ana.410090213
PMID:7235634
Abstract

Postmortem examination of the central nervous system in 6 of 9 patients with central pontine myelinolysis (CPM) revealed demyelination in the lateral geniculate nucleus (LGN). Histologically, the geniculate lesions consisted of myelin swelling and disintegration, largely in the central part of the nucleus, with preservation of axons and neuronal perikarya. The pathological changes resembled those found in the basis pontis in CPM.

摘要

对9例脑桥中央髓鞘溶解症(CPM)患者中的6例进行中枢神经系统尸检,结果显示外侧膝状体(LGN)存在脱髓鞘现象。组织学上,膝状体病变表现为髓鞘肿胀和崩解,主要位于核的中央部分,轴突和神经元胞体得以保留。这些病理变化与CPM中脑桥基底部的病变相似。

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