Miagkova L P, Smotrova I A
Arkh Patol. 1981;43(4):52-8.
Comparative studies of reparative processes in the gastric mucosa were carried out in 96 experimental mice with acute (immobilization) and chronic (acetic acid applications) gastric ulcerations. The common features in both models of ulcerations were revealed: (1) marked reduction of the regeneratory potentials of the epithelium of the entire gastric mucosa early in the ulcer formation as an expression of a stress-reaction; (2) gradual increase of a proliferation pool more marked at the site of the ulcer formation; (3) a sharp increase in the number of DNA-synthesizing cells in the ulcer edges by the time of its morphological formation; (4) extension of the zone of DNA-synthesizing cells with the progression of proliferative processes in the gastric mucosa. The time course of morphological alterations in the gastric mucosa developing in immobilization stress and acetic acid applications reflects the regularities of the development of both local and general reactions of the compensatory-adaptative nature.
对96只患有急性（制动）和慢性（乙酸涂抹）胃溃疡的实验小鼠的胃黏膜修复过程进行了比较研究。两种溃疡模型的共同特征如下：（1）在溃疡形成早期，整个胃黏膜上皮的再生潜能显著降低，这是应激反应的一种表现；（2）增殖池逐渐增加，在溃疡形成部位更为明显；（3）在溃疡形态形成时，溃疡边缘DNA合成细胞数量急剧增加；（4）随着胃黏膜增殖过程的进展，DNA合成细胞区域扩大。制动应激和乙酸涂抹引起的胃黏膜形态学改变的时间进程反映了代偿适应性局部和全身反应的发展规律。
