Callaghan J T, Ausman J I, Clubb R
Arch Neurol. 1981 Jun;38(6):390-1. doi: 10.1001/archneur.1981.00510060092022.
A shunt infection and meningitis developed in a patient receiving methotrexate intravenously for CNS leukemia. Convulsions and respiratory failure followed the intraventricular administration of 300,000 units of penicillin G potassium. Perfusion with 900 mL of Ringer's lactate removed an amount of penicillin equal to that injected intraventricularly plus some from systemic treatment.
一名接受静脉注射甲氨蝶呤治疗中枢神经系统白血病的患者发生了分流感染和脑膜炎。在脑室内注射30万单位青霉素G钾后出现惊厥和呼吸衰竭。用900毫升乳酸林格液灌注清除的青霉素量相当于脑室内注射量加上全身治疗所用的部分量。
