阿霉素与大鼠肝脏微粒体蛋白共价结合的证据。 - Suppr

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Evidence for covalent binding of adriamycin to rat liver microsomal proteins.

作者信息

Ghezzi P, Donelli M G, Pantarotto C, Facchinetti T, Garattini S

出版信息

Biochem Pharmacol. 1981 Jan 15;30(2):175-7. doi: 10.1016/0006-2952(81)90191-x.

DOI:10.1016/0006-2952(81)90191-x

PMID:7236308

Abstract

摘要

相似文献

Evidence for covalent binding of adriamycin to rat liver microsomal proteins.阿霉素与大鼠肝脏微粒体蛋白共价结合的证据。

Biochem Pharmacol. 1981 Jan 15;30(2):175-7. doi: 10.1016/0006-2952(81)90191-x.

Covalent protein binding of reactive adriamycin metabolites in rat liver and rat heart microsomes.阿霉素活性代谢产物在大鼠肝脏和大鼠心脏微粒体中的共价蛋白结合。

J Cancer Res Clin Oncol. 1982;103(1):39-48. doi: 10.1007/BF00410304.

Metabolic activation of adriamycin by NADPH-cytochrome P-450 reductase, rat liver and heart microsomes and covalent protein binding of metabolites.阿霉素通过NADPH-细胞色素P-450还原酶、大鼠肝脏和心脏微粒体的代谢激活以及代谢产物与蛋白质的共价结合。

Adv Exp Med Biol. 1981;136 Pt A:471-85. doi: 10.1007/978-1-4757-0674-1_36.

Enzymatic activation and binding of adriamycin to nuclear DNA.阿霉素与核DNA的酶促活化及结合

Cancer Res. 1984 Jul;44(7):2892-6.

Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparations.

Biochem Pharmacol. 1986 May 15;35(10):1737-42. doi: 10.1016/0006-2952(86)90332-1.

Phosphatidylcholine accessibility in single bilayer vesicles prepared from rat liver microsomal lipids containing proteolipids.从含有蛋白脂质的大鼠肝脏微粒体脂质制备的单层囊泡中磷脂酰胆碱的可及性

Biochem Biophys Res Commun. 1981 May 29;100(2):800-6. doi: 10.1016/s0006-291x(81)80245-8.

Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites.用大鼠肝微粒体对14C-三氯乙烯蒸汽进行温育：放射性摄取及代谢产物与蛋白质的共价结合。

Int Arch Occup Environ Health. 1977 Jun 30;39(2):103-11. doi: 10.1007/BF00380890.

Cytochrome P450 2B1-mediated one-electron reduction of adriamycin: a study with rat liver microsomes and purified enzymes.细胞色素P450 2B1介导的阿霉素单电子还原：大鼠肝微粒体和纯化酶的研究

Mol Pharmacol. 1993 Dec;44(6):1267-77.

Role of one-electron and two-electron reduction products of adriamycin and daunomycin in deoxyribonucleic acid binding.阿霉素和柔红霉素的单电子及双电子还原产物在脱氧核糖核酸结合中的作用

Biochem Pharmacol. 1981 Sep 15;30(18):2626-9. doi: 10.1016/0006-2952(81)90594-3.

Adriamycin stimulates only the iron ion-induced, NADPH-dependent microsomal alkane formation.阿霉素仅刺激铁离子诱导的、依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的微粒体烷烃形成。

Biochem Pharmacol. 1982 Oct 1;31(19):3147-50. doi: 10.1016/0006-2952(82)90101-0.

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Cancer Chemother Pharmacol. 1983;11(1):51-5. doi: 10.1007/BF00257418.

Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin.新型强效蒽环类抗肿瘤抗生素：吗啉柔红霉素、氰基吗啉柔红霉素和氰基吗啉阿霉素诱导DNA加合物形成、DNA交联及染色体畸变

Cell Biol Toxicol. 1985 Jan;1(2):87-101. doi: 10.1007/BF00717794.

A chemical perspective on the anthracycline antitumor antibiotics.蒽环类抗肿瘤抗生素的化学视角

Environ Health Perspect. 1985 Dec;64:4-18. doi: 10.1289/ehp.85644.

Active drug metabolites. An overview of their relevance in clinical pharmacokinetics.活性药物代谢产物。其在临床药代动力学中的相关性概述。

Clin Pharmacokinet. 1985 May-Jun;10(3):216-27. doi: 10.2165/00003088-198510030-00002.

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