Leach L, Whishaw I Q, Kolb B
Behav Brain Res. 1980 Oct;1(5):411-31. doi: 10.1016/0166-4328(80)90038-8.
Electrolytic lesions of the lateral hypothalamus (LH) are known to produce severe and chronic behavioral and electrographic abnormalities. In order to assess the effects of damage to LH cells vs damage to fibers of passage in the LH, a comparison was made of the effects of electrolytic lesions and microinjections of the neurotoxin kainic acid (kainate) in the LH. Behavior and neocortical and hippocampal electroencephalographic (EEG) activity were studied before, immediately after, and for 25 days after the lesions were made. Electrolytic-lesioned rats were aphagic and adipsic, showed an absence of normal atropine-resistant EEG activity, and a release of atropine-sensitive EEG activity in the hippocampus and neocortex. Kainic acid-lesioned rats showed some similar behavioral impairments but the kainate lesions produced different EEG abnormalities, including chronic slow-wave and seizure activity in both the neocortex and hippocampus. Following extended recovery hippocampal EEG was normal despite extensive cellular loss in areas CA3 and CA4. Understanding of the differences in EEG between the electrolytic and kainate effects was compounded by widespread cellular damage in areas outside the hypothalamus in the rats with kainate lesions. Thus, the kainate-produced abnormalities precluded a simple analysis of the contribution that cell damage alone makes to LH lesion-induced behavioral and EEG changes.
已知下丘脑外侧区（LH）的电解损伤会导致严重且慢性的行为和脑电图异常。为了评估LH细胞损伤与LH中传导纤维损伤的影响，对LH进行电解损伤和神经毒素 kainic acid（海藻酸）微注射的效果进行了比较。在损伤前、损伤后立即以及损伤后25天对行为、新皮质和海马脑电图（EEG）活动进行了研究。电解损伤的大鼠出现摄食和饮水减少，海马和新皮质中正常的抗阿托品脑电图活动缺失，且出现对阿托品敏感的脑电图活动。海藻酸损伤的大鼠表现出一些类似的行为损伤，但海藻酸损伤产生了不同的脑电图异常，包括新皮质和海马中的慢性慢波和癫痫活动。经过长时间恢复后，尽管CA3和CA4区存在广泛的细胞丢失，海马脑电图仍恢复正常。在海藻酸损伤的大鼠中，下丘脑外区域存在广泛的细胞损伤，这使得对电解和海藻酸作用之间脑电图差异的理解变得更加复杂。因此，海藻酸产生的异常排除了仅对细胞损伤对LH损伤诱导的行为和脑电图变化的贡献进行简单分析的可能性。
