Danguir J, Nicolaidis S
Brain Res. 1980 Mar 10;185(2):305-21. doi: 10.1016/0006-8993(80)91070-7.
Continuous EEG recordings were performed in lateral hypothalamic (LH) damaged rats from day 1 post-lesion when totally aphagic and adipsic until complete recovery of their feeding and drinking. During the early post-operative stage (days 1--3 post-lesion), LH rats showed a complete disorganization of their basal EEG which was characterized by two superimposed activities, a constant rapid low voltage activity modulated by high voltage low frequency waves. Except in the case of intense illumination, several arousing stimuli did not affect this activity. By day 4 post-lesion, the two overlapping activities were replaced by less abnormal waves on top of which the first normal sleep spindles appeared. Sleep increased gradually and normal amounts of both slow-wave and paradoxical sleep were observed during 'stage 4' of recovery when rats again ate food and drank water. During this stage, and contrary to normal rats, meal size was correlated only with sleep events occurring within the intermeal interval following the next meal, when most of the ingested nutrients reached the systemic compartment. The effect of sleep of intragastric or intravenous caloric repletion was, at least in part, in agreement with the view of indirect effect of LH lesions on sleep through metabolic impairment. Whatever the mechanism underlying sleep deficits, these are one of the major symptoms of the lateral hypothalamic syndrome.
对下丘脑外侧区（LH）损伤的大鼠从损伤后第1天开始进行连续脑电图记录，此时大鼠完全拒食和拒饮，直至其摄食和饮水完全恢复。在术后早期（损伤后第1 - 3天），LH损伤大鼠的基础脑电图完全紊乱，其特征为两种叠加的活动，一种是由高压低频波调制的持续快速低电压活动。除了强光照射的情况外，几种唤醒刺激均不影响这种活动。损伤后第4天，两种重叠活动被不太异常的波所取代，在这些波之上首次出现了正常的睡眠纺锤波。睡眠逐渐增加，在恢复的“第4阶段”，当大鼠再次进食和饮水时，观察到慢波睡眠和异相睡眠的量均正常。在此阶段，与正常大鼠不同的是，餐量仅与下一顿餐后餐间间隔内发生的睡眠事件相关，此时大部分摄入的营养物质进入全身循环。胃内或静脉内热量补充对睡眠的影响至少部分与LH损伤通过代谢损害对睡眠产生间接影响的观点一致。无论睡眠缺陷的潜在机制是什么，这些都是下丘脑外侧综合征的主要症状之一。
