溴脱氧尿苷（BrdU）对人淋巴细胞“体外”细胞周期不同阶段的致断裂效应。
Clastogenic effect of BrdU on different phases of human lymphocyte "in vitro" cell cycle.
作者信息
Ardito G, Lamberti L, Piccotti F
出版信息
Boll Soc Ital Biol Sper. 1981 Feb 15;57(3):259-65.
PMID:7236401
Abstract
From the data presented, it can be pointed out a mitotic delay in the cell cycle, possibly due to BrdU cytotoxic effect. Irradiation in G1 phase does not produce any increase in SCE frequency while irradiation in S or G2 phase increases significantly this frequency. Our data support the hypothesis that BrdU does not produce by itself an increase of chromosome aberrations but act as sensitizer for cells which have incorporated it.
摘要
从所呈现的数据可以指出，细胞周期中存在有丝分裂延迟，这可能是由于BrdU的细胞毒性作用所致。G1期照射不会使姐妹染色单体交换（SCE）频率增加，而S期或G2期照射则会显著增加该频率。我们的数据支持这样的假说，即BrdU本身不会导致染色体畸变增加，而是对已掺入它的细胞起敏化剂的作用。
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