Degli Uberti E, Trasforini G, Margutti A, Rotola C, Lo Vecchio G
Boll Soc Ital Biol Sper. 1981 Feb 28;57(4):367-73.
To investigate the role of serotoninergic system on the control of circadian periodicity of human hypothalamic-pituitary-adrenal axis, effect of a potent 5-HT antagonist, metergoline, on diurnal variation in plasma cortisol levels was studied in five male volunteers. The administration of metergoline did not result in a significant change of plasma cortisol concentrations and its circadian rhythmicity. These results suggest that metergoline does not influence the diurnal secretion of cortisol in normal subjects.
为研究血清素能系统在控制人类下丘脑 - 垂体 - 肾上腺轴昼夜节律中的作用，在五名男性志愿者中研究了强效5 - 羟色胺拮抗剂麦角林对血浆皮质醇水平昼夜变化的影响。给予麦角林后，血浆皮质醇浓度及其昼夜节律没有显著变化。这些结果表明，麦角林不影响正常受试者皮质醇的昼夜分泌。
