Foëx P, Roberts J G, Saner C A, Bennett M J
Br J Anaesth. 1981 May;53(5):463-9. doi: 10.1093/bja/53.5.463.
Oxprenolol is a non-selective adrenergic beta-receptor antagonist displaying beta-mimetic activity. To test the hypothesis that beta-mimetic activity could minimize the response of the circulation to adrenergic beta-receptor blockade, cumulative dose-response curves to oxprenolol 0.1-1.6 mg kg-1 were obtained in seven anaesthetized dogs. Anaesthesia was maintained with 0.5% halothane supplementing nitrous oxide 66% in oxygen, under moderately hypocapnic IPPV. Oxprenolol, up to 0.4 mg kg-1 i.v., caused modest increases in heart rate, LV dP/dt max and cardiac output. With the largest dose (1.6 mg kg-1), significant increases in heart rate (+19%), LV dP/dt max (+13%) and cardiac output (+27%) were observed while arterial pressure remained unchanged and systemic vascular resistance decreased (-18%).
氧烯洛尔是一种具有β-拟似活性的非选择性肾上腺素能β受体拮抗剂。为了验证β-拟似活性可使循环系统对肾上腺素能β受体阻滞的反应降至最低这一假说，对7只麻醉犬给予0.1 - 1.6mg/kg的氧烯洛尔，得到累积剂量-反应曲线。在中度低碳酸血症的间歇正压通气下，用0.5%氟烷加66%氧化亚氮和氧气维持麻醉。静脉注射高达0.4mg/kg的氧烯洛尔可使心率、左心室dp/dt max和心输出量适度增加。使用最大剂量（1.6mg/kg）时，心率显著增加（+19%）、左心室dp/dt max显著增加（+13%）、心输出量显著增加（+27%），而动脉压保持不变，全身血管阻力降低（-18%）。
