Foëx P, Ryder W A
Br J Anaesth. 1981 Jan;53(1):19-26. doi: 10.1093/bja/53.1.19.
Effects of change in PaCO2 on systemic and coronary haemodynamics and on coronary sinus blood-gases have been studied in 10 open-chested dogs in which the lungs were ventilated with 0.8% halothane in oxygen, before and after administration of oxprenolol 0.3 mg kg-1 i.v. The hyperdynamic response of the circulation to hypercapnia was only marginally reduced after oxprenolol (cardiac output increased by 10% as opposed to 16% before oxprenolol). Before and after oxprenolol, hypocapnia caused large reductions of coronary blood flow (--24% and --20% respectively), while hypercapnia caused large increases of coronary blood flow (+ 59% and + 34% respectively). Oxprenolol does not appear to modify significantly the circulatory response to arterial carbon tension.
在10只开胸犬中，研究了动脉血二氧化碳分压（PaCO2）变化对全身和冠状动脉血流动力学以及冠状窦血气的影响。这些犬在静脉注射0.3mg/kg氧烯洛尔前后，均用含0.8%氟烷的氧气进行肺通气。氧烯洛尔注射后，循环系统对高碳酸血症的高动力反应仅略有降低（心输出量增加10%，而氧烯洛尔注射前为16%）。在氧烯洛尔注射前后，低碳酸血症均导致冠状动脉血流量大幅减少（分别为-24%和-20%），而高碳酸血症则导致冠状动脉血流量大幅增加（分别为+59%和+34%）。氧烯洛尔似乎并未显著改变对动脉二氧化碳张力的循环反应。
