细胞毒性药物与米索硝唑联合使用增强对Lewis肺癌和人胰腺癌异种移植瘤的细胞杀伤作用。
Enhanced cell killing in lewis lung carcinoma and a human pancreatic-carcinoma xenograft by the combination of cytotoxic drugs and misonidazole.
作者信息
Stephens T C, Courtenay V D, Mills J, Peacock J H, Rose C M, Spooner D
出版信息
Br J Cancer. 1981 Apr;43(4):451-7. doi: 10.1038/bjc.1981.66.
Abstract
The "chemosensitizing" properties of the radiosensitizer misonidazole (MISO) were examined in 2 tumour systems, murine Lewis lung carcinoma and human pancreatic adenocarcinoma xenografted into immune-suppressed mice, using a soft-agar colony assay to measure tumour-cell survival. In mice bearing Lewis lung tumour, the administration of MISO simultaneously with melphalan, cyclophosphamide. CCNU, FU or vincristine gave substantial enhancement of cytotoxicity (DEFs from 1.5 to 3.5). However, no enhancement was seen with bleomycin, VP 16-213 or cis-Pt. The same level of enhancement of cyclophosphamide effect (DEF = 2.0) was seen with both cell survival and growth delay end-points effect (DEF = 2.0) was seen with both cell survival and growth delay end-points of tumour response. Enhancement was also seen in the human tumour xenograft with melphalan, cyclophosphamide and MeCCNU, using a cell survival assay, but cis-Pt was again not enhanced.
摘要
利用软琼脂集落试验来测定肿瘤细胞存活率，在两种肿瘤系统（移植到免疫抑制小鼠体内的小鼠Lewis肺癌和人胰腺腺癌）中研究了放射增敏剂米索硝唑（MISO）的“化学增敏”特性。在携带Lewis肺癌的小鼠中，将MISO与美法仑、环磷酰胺、洛莫司汀、氟尿嘧啶或长春新碱同时给药，可显著增强细胞毒性（增敏因子为1.5至3.5）。然而，博来霉素、依托泊苷或顺铂未观察到增敏作用。在肿瘤反应的细胞存活和生长延迟终点方面，环磷酰胺效应的增敏水平相同（增敏因子 = 2.0）。在人肿瘤异种移植模型中，使用细胞存活试验，美法仑、环磷酰胺和甲基洛莫司汀也观察到了增敏作用，但顺铂同样未增强。
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Cell yield and cell survival following chemotherapy of the B16 melanoma.B16黑色素瘤化疗后的细胞产量和细胞存活率。
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Repopulation of gamma-irradiated Lewis lung carcinoma by malignant cells and host macrophage progenitors.恶性细胞和宿主巨噬细胞祖细胞对经γ射线照射的Lewis肺癌进行再增殖。
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