Dent R G, Cole P
Br J Cancer. 1981 Apr;43(4):486-95. doi: 10.1038/bjc.1981.71.
Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients with chronic obstructive airways disease and controls matched for age, sex, smoking history, respiratory function and the presence of infection. Maturation of monocytes from patients with terminal non-malignant disease was depressed, though not to the same extent as in those with extensive malignancy. Monocytes from relatives of patients with squamous-cell carcinoma of the lung matured normally. In 10 patients with limited disease, in vitro monocyte maturation was repeated 6-12 weeks after operation, and was found to relate to prognosis.
通过定量微量滴定法对肺癌鳞状细胞癌患者的单核细胞在体外成熟为巨噬细胞的过程进行了测定。与正常对照组、慢性阻塞性气道疾病患者以及年龄、性别、吸烟史、呼吸功能和有无感染相匹配的对照组相比，局限性和广泛性疾病患者自体血清中的单核细胞成熟度均显著降低。终末期非恶性疾病患者的单核细胞成熟度也有所降低，不过程度不及广泛性恶性疾病患者。肺癌鳞状细胞癌患者亲属的单核细胞正常成熟。对10例局限性疾病患者在术后6 - 12周重复进行体外单核细胞成熟度测定，发现其与预后相关。
