Sokol R J, Wales J, Norris P D, Hudson G
J Anat. 1982 Oct;135(Pt 3):615-24.
Ultrastructural studies have been made of skin window inflammatory cells in 22 healthy human subjects at 24 hours and 48 hours after an initial abrasion. Large numbers of macrophages and neutrophil polymorphs were seen at both intervals. Compared with the 24 hours specimens, macrophages at 48 hours tended to have more eccentric and less irregular nuclei, as well as more voluminous cytoplasm; phagosomes and large vacuoles were much more prominent and cell diameters were larger. The differences are consistent with maturational changes in the macrophages during the inflammatory response. In the neutrophil polymorphs, the nuclei were frequently pycnotic and showed multiple profiles, and the complement of granules was small. Other cell types were only occasionally encountered. It is concluded that ultrastructural studies of skin window cells may have an application in investigating maturational defects of macrophages in malignant states.
对22名健康人体受试者初次擦伤后24小时和48小时的皮肤窗炎症细胞进行了超微结构研究。在两个时间点均可见大量巨噬细胞和中性粒细胞多形核白细胞。与24小时的标本相比，48小时的巨噬细胞核更偏向一侧且不规则程度更低，细胞质更丰富；吞噬体和大液泡更为显著，细胞直径更大。这些差异与炎症反应期间巨噬细胞的成熟变化一致。在中性粒细胞多形核白细胞中，细胞核常呈固缩状且呈现多个形态，颗粒成分较少。其他细胞类型仅偶尔见到。结论是，皮肤窗细胞的超微结构研究可能在调查恶性状态下巨噬细胞的成熟缺陷方面有应用价值。
