Johansen K A, Williams J H, Stark J M
Br J Obstet Gynaecol. 1981 May;88(5):504-12. doi: 10.1111/j.1471-0528.1981.tb01024.x.
A prospective study of 61 women who were normotensive at booking revealed an increased incidence of C56-forming ability in those who later developed hypertension. Similar changes were found before delivery in a separate group of women admitted with latent hypertension and in each of 11 women with severe pre-eclampsia and a surviving fetus. The C56-forming ability, an acute phase feature, often preceded the hypertension and the findings suggest an indirect relation between complement changes and the mechanism causing hypertension in pregnancy. Concentrations of complement components in hypertensive and normotensive pregnancies were also compared with each other and with those of normal healthy non-pregnant women. The hypertensive patients had increased total alternative pathway function and higher factor B concentrations. The C56-negative sera from hypertensive patients tended to have C7 concentrations higher than normal whereas C56-positive patients had higher C5 concentrations. The aetiological and pathological implications are discussed.
一项针对61名在孕早期血压正常的女性的前瞻性研究发现，后来患高血压的女性中C56形成能力的发生率增加。在另一组患有隐匿性高血压的入院女性以及11名患有重度子痫前期且胎儿存活的女性中，在分娩前也发现了类似变化。C56形成能力是一种急性期特征，通常先于高血压出现，研究结果表明补体变化与妊娠高血压发病机制之间存在间接关系。还比较了高血压妊娠和血压正常妊娠中补体成分的浓度，并与正常健康未孕女性的补体成分浓度进行了比较。高血压患者的总替代途径功能增强，B因子浓度更高。高血压患者的C56阴性血清C7浓度往往高于正常水平，而C56阳性患者的C5浓度更高。文中讨论了其病因学和病理学意义。
