Mak L W
Clin Exp Immunol. 1978 Mar;31(3):419-25.
C56 (activated "reactor") could be generated by adding zymosan to only nineteen out of the fifty serum samples obtained from southern Chinese women 3 to 5 days after a normal spontaneous delivery. As a group, post-partum sera showed a 25% increase in total haemolytic complement, an almost two-fold increase in haemolytic C5, C4 and C8 plus C9 activity, a 50% increase in antigenic C3 and haemolytic C2, C1 and factor B activity, a less than 20% increase in haemolytic C6 and C7 activity, and a 20% decrease in factor D and C1 inhibitor activity. Consequently, their C5:C7 ratios were significantly elevated. This finding supports, in part, the theory that the "reactor" state or ability to generate C56 depends on a relative excess of C56 over C7. However, comparison of the complement profile between sera with and those without "reactor" activity did not reveal any difference, except a greater elevation of C5 in the latter. It appears possible that a grossly excessive level of C5 may, in fact, be unfavourable to the generation of C56.
通过向50份从中国南方女性正常自然分娩后3至5天采集的血清样本中的19份添加酵母聚糖，可以生成C56（活化的“反应体”）。作为一个整体，产后血清的总溶血补体增加了25%，溶血C5、C4以及C8加C9活性几乎增加了两倍，抗原性C3以及溶血C2、C1和B因子活性增加了50%，溶血C6和C7活性增加不到20%，D因子和C1抑制剂活性降低了20%。因此，它们的C5:C7比值显著升高。这一发现部分支持了“反应体”状态或生成C56的能力取决于C56相对于C7相对过量的理论。然而，有“反应体”活性和无“反应体”活性的血清之间的补体谱比较未发现任何差异，只是后者的C5升高幅度更大。实际上，C5水平过高可能不利于C56的生成。
