对猫闰绍细胞上乙酰胆碱受体的重新评估。
A re-evaluation of acetylcholine receptors on feline Renshaw cells.
作者信息
King K T, Ryall R W
出版信息
Br J Pharmacol. 1981 Jun;73(2):455-60. doi: 10.1111/j.1476-5381.1981.tb10442.x.
Abstract
1 The effects of atropine, methylatropine and lachesine administered by ionophoresis were examined on responses of Renshaw cells to acetylcholine, acetyl-beta-methylcholine, nicotine and DL-muscarine in cats anaesthetized with pentobarbitone or chloralose. 2 The antagonists were as effective in antagonizing excitation by nicotine as they were in antagonizing excitation by acetylcholine and were only slightly more effective in antagonizing excitation by acetyl-beta-methylcholine. 3 These results are discussed in relation to the characterization of acetylcholine receptors on Renshaw cells. 4 It is concluded that there are two distinct populations of receptors but that the nicotinic receptors are non-selective in their activation by agonists and antagonists, whereas the muscarinic receptors display greater selectivity.
摘要
- 研究了在戊巴比妥或氯醛糖麻醉的猫中，通过离子电泳给予阿托品、甲基阿托品和拉切辛对闰绍细胞对乙酰胆碱、乙酰-β-甲基胆碱、尼古丁和DL-毒蕈碱反应的影响。2. 这些拮抗剂在拮抗尼古丁引起的兴奋方面与拮抗乙酰胆碱引起的兴奋一样有效，而在拮抗乙酰-β-甲基胆碱引起的兴奋方面仅略有效。3. 结合闰绍细胞上乙酰胆碱受体的特性对这些结果进行了讨论。4. 得出的结论是，存在两种不同的受体群体，但烟碱样受体在激动剂和拮抗剂激活方面是非选择性的，而毒蕈碱样受体表现出更大的选择性。
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本文引用的文献
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The synaptic excitation of Renshaw cells.闰绍细胞的突触兴奋。
Exp Brain Res. 1966;2(1):81-96. doi: 10.1007/BF00234362.
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The acetylcholine receptors of Renshaw cells.闰绍细胞的乙酰胆碱受体。
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The excitation of Renshaw cells by cholinomimetics.拟胆碱药对闰绍细胞的兴奋作用。
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Actions of pancuronium on Renshaw cells of the rat spinal cord.泮库溴铵对大鼠脊髓闰绍细胞的作用。
Comp Gen Pharmacol. 1973 Jun;4(14):179-81. doi: 10.1016/0010-4035(73)90037-2.
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Renshaw cell mediated inhibition of Renshaw cells: patterns of excitation and inhibition from impulses in motor axon collaterals.闰绍细胞介导的闰绍细胞抑制：运动轴突侧支冲动产生的兴奋和抑制模式。
J Neurophysiol. 1970 Mar;33(2):257-70. doi: 10.1152/jn.1970.33.2.257.
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Alpha-bungarotoxin, cobra neurotoxin and excitation of Renshaw cells by acetylcholine.α-银环蛇毒素、眼镜蛇神经毒素与乙酰胆碱对闰绍细胞的兴奋作用
Brain Res. 1976 Apr 30;107(1):166-70. doi: 10.1016/0006-8993(76)90106-2.
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Acetylcholine receptors on Renshaw cells of the rat.大鼠闰绍细胞上的乙酰胆碱受体。
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J Physiol. 1979 Apr;289:77P-78P.
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