1-甲基-5-氯吲哚啉甲基溴（S-6）对猫的闰绍细胞的作用。

Effects of 1-methyl-5-chloroindoline methylbromide (S-6) on Renshaw cells of cats.

作者信息

Irikura T, Ohkubo H, Hirayama T, Nishino K

出版信息

Jpn J Pharmacol. 1977 Feb;27(1):39-45. doi: 10.1254/jjp.27.39.

DOI:10.1254/jjp.27.39

Abstract

Effects of 1-methyl-5-chloroindoline methylbromide (S-6) on Renshaw cells were investigated in cats anesthetized with pentobarbital sodium. S-6 proved to have little effect on spike discharges of Renshaw cells when administered intravenously, but the agent electrophoretically applied revealed excitatory effects which resembled the action of methacholine and such effects were blocked by intravenous administration of atropine. It was conlcuded that (1) S-6 is impermeant to the blood brain barrier and (2) the excitatory action of S-6 on Renshaw cells is muscarinic in nature.

摘要

在用戊巴比妥钠麻醉的猫身上研究了1-甲基-5-氯吲哚啉甲基溴（S-6）对闰绍细胞的作用。静脉注射S-6时，其对闰绍细胞的锋电位发放几乎没有影响，但电泳施加该药物则显示出兴奋作用，类似于乙酰甲胆碱的作用，并且这种作用可被静脉注射阿托品阻断。得出的结论是：（1）S-6不能透过血脑屏障；（2）S-6对闰绍细胞的兴奋作用本质上是毒蕈碱样的。