Kwong T C, Rothbard R L, Biddle T L
Clin Chem. 1981 Jun;27(6):828-31.
A new radiometric assay specific for creatine kinase isoenzyme MB was evaluated with respect to its precision and agreement with a conventional electrophoretic CK-MB assay for the diagnosis of myocardial infarction. The reference interval we find for serum CK-MB in healthy subjects is 0--30 micrograms/L. The coefficients of variation at 197 and 40 micrograms of CK-MB per liter, were 5.2 and 11.5%, respectively. In a clinical study of 52 consecutive patients admitted into a Coronary Care Unit with a diagnosis of suspected myocardial infarction, there was overall agreement in CK-MB results by the two assays for 51 of 52 patients. A more sensitive and quantitative assay that is specific for CK-MB can be helpful in cases where diagnosis of myocardial infarction is equivocal.
针对一种新的、特异性检测肌酸激酶同工酶MB的放射分析方法，评估了其精密度以及与传统的电泳法检测CK-MB在诊断心肌梗死方面的一致性。我们发现健康受试者血清CK-MB的参考区间为0-30微克/升。每升含197微克和40微克CK-MB时的变异系数分别为5.2%和11.5%。在一项针对52例连续入住冠心病监护病房、诊断为疑似心肌梗死患者的临床研究中，两种检测方法对52例患者中的51例CK-MB检测结果总体一致。一种对CK-MB具有特异性、更灵敏且定量的检测方法，在心肌梗死诊断不明确的情况下可能会有帮助。
