Landahl S, Jagenburg R, Svanborg A
Clin Chim Acta. 1981 May;112(3):301-14. doi: 10.1016/0009-8981(81)90453-8.
The concentrations of many blood components change with age, and the aim of the present study was to determine, at the age of 70, the concentrations of blood components commonly used in clinical routine, and to examine how the exclusion of probands with disease influenced their distribution. In connection with a longitudinal population study "70-year-old people in Göteborg" 30 blood components have been analyzed in a representative sample of 973 70-year-old men and women. 29% of the probands were found to be without definable disease or treatment for presumed disease. Concentrations of 13 components were found to have a gaussian distribution which was not altered after the exclusion of probands with definable disease. Three components were asymmetrically distributed in the total material and showed a normal distribution with decreased concentrations at the 97.8% level after the exclusion of probands with definable disease. The remaining 14 components had asymmetrically distributed concentrations both in the total material and in the subjects without definable diseases. For blood components with normally distributed concentrations in the probands without definable disease, acceptable reference values could be obtained without exclusion of sick probands. For asymmetrically distributed blood components the concentration at the 97.8% level usually decreased more, after exclusion of probands with definable disease, the more asymmetric the distribution was. Examples of reference intervals are (men and women) B-Hb: 130--171 and 119--159 g/l, S-iron: 6--29 and 5--28 mumol/l, S-creatinine: 52--110 and 44--100 mumol/l, P-cholesterol: 3.6--9.2 and 4.6--9.7 mmol/l, P-B12: 50--350 and 65--390 pmol/l, B-ESR: 1--30 and 2--34 mm/h and B-glucose: 4.0--7.2 and 4.0--6.8 mmol/l.
许多血液成分的浓度会随着年龄而变化，本研究的目的是测定70岁时临床常规常用血液成分的浓度，并研究排除患有疾病的先证者如何影响其分布情况。在一项名为“哥德堡70岁人群”的纵向人群研究中，对973名70岁男性和女性的代表性样本中的30种血液成分进行了分析。发现29%的先证者没有可明确诊断的疾病或针对疑似疾病的治疗。发现13种成分的浓度呈高斯分布，在排除患有可明确诊断疾病的先证者后，这种分布未发生改变。三种成分在整个样本中呈不对称分布，在排除患有可明确诊断疾病的先证者后，在97.8%水平上显示出浓度降低的正态分布。其余14种成分在整个样本以及没有可明确诊断疾病的受试者中浓度均呈不对称分布。对于在先证者中浓度呈正态分布且无可明确诊断疾病的血液成分，无需排除患病先证者即可获得可接受的参考值。对于分布不对称的血液成分，排除患有可明确诊断疾病的先证者后，97.8%水平的浓度通常下降得更多，分布越不对称下降越明显。参考区间示例（男性和女性）：血红蛋白（B-Hb）：130--171和119--159克/升，血清铁（S-iron）：6--29和5--28微摩尔/升，血清肌酐（S-creatinine）：52--110和44--100微摩尔/升，总胆固醇（P-cholesterol）：3.6--9.2和4.6--9.7毫摩尔/升，维生素B12（P-B12）：50--350和65--390皮摩尔/升，红细胞沉降率（B-ESR）：1--30和2--34毫米/小时，血糖（B-glucose）：4.0--7.2和4.0--6.8毫摩尔/升。
