Maupas P, Goudeau A, Coursaget P, Drucker J, Bagros P, Baudin S, Geslin N
Med Microbiol Immunol. 1978 Nov 17;166(1-4):109-18. doi: 10.1007/BF02121140.
The development of a vaccine against hepatitis B prepared with purified and inactivated HBs Ag is described. This vaccine has been applied in patients and staff members of haemodialysis centres. Safety and efficiency of the vaccine are very satisfactory. The response of patients to immunisation was significantly lower compared to the response of the staff members. None of the volunteers who had a primary response to immunisation developed signs of clinical or biological hepatitis.
描述了一种用纯化和灭活的乙肝表面抗原制备的乙肝疫苗的研发情况。该疫苗已应用于血液透析中心的患者和工作人员。疫苗的安全性和有效性非常令人满意。患者对免疫接种的反应明显低于工作人员。对免疫接种产生初次反应的志愿者均未出现临床或生物学肝炎的迹象。
